Clomid for men - treatment of his infertility - uses Clomiphen in male
One of the reasons for the inability of a married couple to conceive a baby is male infertility. Most often it is caused by oligospermia. Oligospermia is a low number of viable sperm in a man. Pathology does not give any manifestations, and it can be detected only with a competently evaluated spermogram. To increase her performance and increase the chance of pregnancy, Clomid is prescribed. This drug originally aimed to solve women's problems with contraception. In the future, the drug was part of a complex therapy to combat anovulatory infertility, and subsequently it was used for weak ejaculate in men.
- What Is Clomid?
- How it works?
- What is the effectiveness of male infertility treatment?
- When can a man be prescribed Clomid?
- Dosage and treatment
- What side effects are possible when taking Clomid?
- What are the contraindications of the drug?
- How often are twins born when using Clomid?
- Other treatments for male factor infertility
- Nutrition that increases male fertility
What Is Clomid?
Clomid is a non-steroidal agent for suppressing estrogen (female sex hormones) and stimulating ovulation. In relation to men, the drug is used to increase gonadotropins, low levels of which indicate oligospermia. Long-term use of the drug stimulates the quality of the ejaculate produced. Another purpose of the drug was discovered by bodybuilders, noting its ability to maintain a good physical condition.
The release of the drug is engaged in many pharmaceutical companies including SANOFI-AVENTIS. By the way, this drug is tested and approved by the FDA. The main active component of Clomid is clomiphene citrate, obtained by chemical synthesis. One tablet of the active substance accounts for 50 mg. also in the composition contains auxiliary ingredients:
- Lactose monohydrate
- Stearic acid
- Starch, etc.
How it works?
Spermatogenesis in the male body is controlled by hormones. This process begins with the period of puberty and is due to the mutual influence of the hypothalamus, pituitary, Leydig cells of the testicles (the mechanisms of interaction are complex for the layman, for a better understanding, read the relevant literature). In case of violation of the humoral link of interaction of these anatomical structures (lack of one of the hormones), there is a change in sperm synthesis, which must be treated with Clomphen-replacement treatment. The hormone (estrogen) in the composition of the drug Clomid restores a complex chain of humoral connections in the male body, normalizes spermatogenesis as a result. To suspect such a breach gives and and related symptoms. For example, delayed puberty in the past, poor health, and more.
What is the effectiveness of male infertility treatment?
The tool is affordable and easy to use. It does not require strict adherence to the time of reception. For effective action enough daily use, so as not to knock the course.
According to statistics, regular intake of the prescribed drug improves the quality and quantity of sperm in 89% of men. Patients themselves note that with the use of drugs decreases immunity, so it is desirable to take vitamins at the same time.
As for weight gain, this fact is confirmed by about 40% of men. This is due to hormonal changes in the body. It is enough to consult a doctor, review the diet and start moving more. To get the weight readings back to normal.
When can a man be prescribed Clomid?
The drug can be prescribed to a man to raise the level of fertility(the ability to have children). The drug affects in two ways:
- The change in the quality of sperm
- Updating the hormonal environment of the body
Treatment with the drug may not require other methods for infertility couples, including surgery and IVF. In case of failure to achieve the result(pregnancy) – there will be hormonal preparation of the body for IVF.
Pathology, due to the lack of male hormones, in 95% of this testosterone-called hypogonadism. Clomid can be prescribed for the treatment of hypogonadotropic hypogonadism of any nature. In this direction, the action will be directed through the pituitary and hypothalamus to the testicles. In turn, the levels of LH(luteinizing hormone) and FSH(follicle stimulating hormone) will change. And FSH is inextricably linked to testosterone. The level of which increases after such therapy. A positive outcome reaches 100% if the disease has a hypogonadotropic theology. It is characterized by symptoms:
- Hair loss or poor hair growth
- Weight loss
- Inhibition or regression of muscle mass
- Problems with concentration
- Heat flashes
- ED or erectile dysfunction
- Problems with libido
Dilation of the plexus of the veins, in most cases on the left side, of the testicles or scrotum. There is only one correct way of treatment-this varicocelectomy (surgery to remove varicocele). Clomid in this regard can only be considered as a drug for a partner. Varicocele can cause male infertility, but not in 100% of cases. With absolute fertility of the partner, surgery in the varicocele will be necessary.
Idiopathic remedies of unknown cause. Oligoasthenozoospermia means low sperm count and poor sperm motility. If a sperm test finds that you have a low sperm count and poor mobility, but your doctor can't explain why you have this problem, he can diagnose you with idiopathic oligoastenozoospermia. Clomid is one possible treatment option.
Azoospermia means that there are no sperm in the sperm. No obstruction means no physical blockage preventing sperm from entering the ejaculate.
In azoospermia, clomid may be prescribed to help create and increase sperm count. Even if this fails, clomid can increase the chances of successful sperm extraction or testicular biopsy (this is where immature sperm are extracted through a needle directly from the testicles and then Mature in the laboratory).
Dosage and treatment
To speed up the onset of the desired pregnancy, you do not need to violate the doctor's recommendations on taking medications. The instruction enclosed in the package of Clomid is designed mainly for female patients. The dosage for men is determined by the andrologist or reproductologist, depending on the parameters of the tests.
When diagnosed with oligospermia is a single daily intake of 50 mg or 1 tablet. The standard course of treatment lasts 6 weeks, during which a spermogram is performed every 14 days. The tablet is washed down with water without chewing. In the absence of proper effect, it is possible to prolong the treatment course and increase the dosage. However, the weekly dose of the drug should not be more than 750 mg.
What side effects are possible when taking Clomid?
The active component clomiphene citrate is excreted from the cells of the body for a long time, within 7-10 days. But this factor as a result has the main effect of treatment. Such a long delay of the substance provokes ovulation in women, and the ejaculate of a man becomes filled with a large number of active and viable sperm.
System of digestion. In a state of intoxication or hangover, the use of tablets leads to intoxication and poisoning. Alcohol tends to enhance the effect of the drug, which is fraught with an overdose or even zero it.
Integument. Persons prone to allergies, Clomid may not be suitable. This will manifest itself in the form of a rash, which will last for a long time, as the excretion of the drug lasts at least 7 days.
Gastrointestinal tract. Excretion of the active component occurs together with the feces, which in the presence of pathologies of the gastrointestinal tract is fraught with a disorder of the chair, colic. With improper nutrition, overweight, lack of mobility, constipation is possible.
Central nervous system. Not often, but there are cases of side effects in the form of dizziness, headaches. Bright dreams of an erotic nature are possible. Another reaction of the nervous system is insomnia, so it is better to take pills in the morning or during the day, long before sleep. Some patients become emotionally depressed. An explanation for this condition has not yet been found.
Genitourinary system. At evening reception of medicine there are frequent urges to urinate.
From other negative manifestations in men can be noted:
- Weight gain
- Short-term visual acuity impairment
- Depressed mood
If such conditions occur, clomid should be stopped immediately. Clomid is able to affect one or more vital systems of the body, individually for each patient, based on physiological characteristics.
What are the contraindications of the drug?
Basically, the "male" reception of Clomid is indicated when planning a pregnancy. But the expediency of its appointment is determined only by the doctor. If you do not take into account purely female contraindications, the drug is prohibited for men in the following cases:
- Lactose intolerance
- Diseases of the visual organs (chronic and acute phase)
- Pathology of the kidneys and liver
- Tumors of unknown etiology on the genitals
- Disorders of the thyroid gland and adrenal glands
- Pathology of the pituitary (tumor, underactive)
As far as the remedy is effective against both sexes, so it is harmful.
The main contraindication to taking the drug is the dysfunction of any organ of a man or woman responsible for the production of any hormone.
How often are twins born when using Clomid?
There are still so-called surprises that this medicine prepares. Medical workers warn that after taking a course of the drug there is a possibility, and rather big, to get pregnant with twins. Ten percent of conceptions that occurred after receiving Clostilbegyt become prolific.
It can not but rejoice and the fact that this medicine is not dangerous for the child. Also, there is no evidence that after taking the drug, the child may have all sorts of abnormalities.
But there is one small minus: toxicosis in this pregnancy can be stronger than usual. The main thing is required to monitor the state of the liver.
Other treatments for male factor infertility?
Not always the treatment of male infertility can be defeated with only one drug, though as effective as Clomiphene. Usually the treatment, depending on the causes that caused it, involves the following steps:
The lifestyle change
Motto: bodybuilding to get pregnant. In the male case, it is male fertility. If you lead a sporty lifestyle, do not smoke and do not drink alcohol-then you are on the right track. In addition, do not overheat, cool down. The main thing at this stage is to cut off all negative external provoking causes. This method can increase fertility by 50%.
It happens that a change of lifestyle does not give the desired result. Then you need to start drug therapy. It is important to choose a group of drugs that will eliminate the cause of the disease. Since there may be several reasons, male infertility pills also differ in pharmacological groups and indications. Taking them without prescription is dangerous – it will exacerbate the problem.
As drugs for the treatment of male infertility, antibiotics are effective if the cause of the disease is infection. The drug is selected after bacteriological sowing of seminal fluid. Erythromycin, Ofloxacin, Metronidazole and others.
Hormonal pills for infertility are prescribed if the results of a blood test, the doctor finds an excess or lack of hormones. This tactic helps to cure infertility in men, if fertility was affected by hormonal abnormalities.
- androgens - testosterone propionate
- gonadotropin - chorionic gonadotropin (HCG) stimulates spermatogenesis in men
- bromocriptine is a dopamine receptor stimulant prescribed for metabolic disorders with decreased sexual function
The doctor can choose a complex that has all the necessary vitamins and mineral supplements. In large quantities, they are found in products-aphrodisiacs. Get a dose that our body is able to absorb better from vitamin complexes.
Vitamins necessary for normal sexual function in men:
- Folic acid
- ascorbic acid
- vitamin A
- B1, B5, B6
One of the methods of treatment of male infertility is surgery. Operations are carried out with obturation form of infertility and diseases associated with genetic abnormalities of the structure of the genitals. This form of infertility is associated with the wrong structure of the VAS deferens, which occurs due to injuries, inflammation and congenital anatomical abnormalities. Manifests itself in more than 10% of cases. Varicocele disease belongs to this group.
Assisted reproductive technology
Assisted reproductive technology is the collective name of all the methods that a doctor will offer a man with diagnosed infertility to conceive a child. The most famous method is in Vitro fertilization of the egg. The appropriate technology is also chosen depending on the cause of the disease in men, taking into account the sexual health of women. This is the procedure of conception in vitro. From ovaries select an egg after hormonal stimulation or in a natural cycle, from the man take sperm for fertilization.
Intracytoplasmic sperm injection
The procedure is similar to the one described above, only in this case the germ cells do not just connect for fertilization. A mobile and qualitative sperm is selected and injected into the cytoplasm of the egg. Unlike conventional IVF, the sperm has no "rivals" - the injection allows you to immediately fertilize the cell.
Nutrition that increases male fertility
Lists of specific dishes and products can give not quite the right picture on the diet of men with infertility, besides all have individual characteristics. We'll just focus your attention on a few tips:
- Vitamin A, which is contained in oatmeal, dried apricots, broccoli, spinach favors an increase in the number of sperm and their mobility in the ejaculator. Bring your daily intake of this vitamin to the recommended level and your chances will increase
- Zinc-containing products. Seafood, pumpkin seeds, Turkey, beef will help to raise testosterone levels
- Omega 3 fatty acids. In the sperm of patients who do not experience infertility-much more of these acids than in infertile men. To increase the level of acid you need to eat crabs, shrimp, flax, salmon, anchovies. This food will give blood flow to the pelvic organs. The consequence will be an increase in erection
- Vitamin C is very conducive to sperm viability. A lot of it is found in yellow fruits and vegetables. Lemon, Cabbage (white), kiwi, orange, parsley
- Eat more foods containing folic acid. The lack of this component contributes to the production of sperm with chromosomal abnormalities. This can cause miscarriage and birth defects. The lack can be made up from the tablet component, as well as from dark green vegetables, whole grains, beans.
Also, studies have shown that those who smoke marijuana can be impaired fertility due to the harmful effects of the main component of the drug on the ability of sperm to penetrate into female eggs for fertilization.
- Clomid is useful in male infertility. In some cases, this drug is the only one to solve problems with male fertility
- In order to confirm the need for its use, a number of tests are done, including spermogram, hormonal analysis, testosterone analysis, FSH and LH analysis
- The main directions of drug administration:
- Increase in testosterone
- With established treatment with clomiphene, the drug is taken once a day at a dosage of 50mg for 2-6 months. Once every 14 days, a control analysis of sperm is done
- If all the subtleties of taking the drug are observed, side effects rarely manifest themselves. Do not exceed the weekly dose of the drug. It is 700 mg