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Clomid for woman! When treatment will be effective?

Clomid for her

Clomid is a pill for women and men that increases the chance of getting pregnant and prolonging the birth of a infertile couple. The drug includes clomiphene citrate, which inhibits the formation of estrogen. Due to this, the drug belongs to the group of antiestrogens. However, Clomid contributes to the production of the hormones FSH and LH, which are necessary for the occurrence of ovulation in women and increase the level of testosterone in men. The substance is quickly absorbed into the blood, but is excreted from the body for a long time – the half-life is about 5-7 days.


Who is this drug for?

Although the drug is successfully used in the treatment of infertility of both sexes, it was developed specifically for women. It is certified by the FDA as a means to stimulate ovulation. The reasons for the lack of ovulation can be:

  • Chiari-Frommel Syndrome. In this case, the patient has amenorrhea, as well as atrophy of the external genitals. There may be slight discharge from the nipples. Because of this pathology, the natural process of ovulation is disrupted.
  • Polycystic ovary. This is manifested by the lack of ovulation, increased production of sex hormones (androgens and estrogens).
  • Amenorrhea syndrome. In this case, the woman disappears menstruation, ovulation becomes unstable or disappears altogether. This condition may be caused by taking some oral contraceptives, so before starting treatment for Clostibelgitis, you should stop taking any hormonal agents.

Can you buy clomid online?

Clomid is sold in almost any pharmacy, but of course it is more convenient to buy it online. The cost of packaging is from $18 to $35 for 10 pieces. Be prepared for the fact that the pills will be sold to you by a doctor's prescription and if you have a prescription. Therefore, you should seek help from a specialist. Self-medication is not recommended. This can lead to hormonal disorders, ovarian enlargement, and other serious consequences.


Taking

Clomid – a very effective drug that gives a chance to feel the joy of motherhood to many women. However, treatment should begin only on the appointment of a specialist and take place under his close supervision.

By the way, the key word here is "specialist". You must be absolutely sure that your doctor has complied with all the rules related to the use of the drug:

  1. Before ovulation is stimulated, you should have tests and ultrasound monitoring to make sure that there is no ovulation. The purpose of the drug should not be based only on the basal temperature chart!
  2. The doctor must make sure that the fallopian tubes are passable.
  3. Before prescribing the drug, you need to examine the husband, in particular, you need fresh spermogram results.
  4. Ultrasound monitoring of stimulation should be performed every cycle, starting from the very first cycle.

Treatment

Clomid therapy is performed between the 5th and 9th day of the menstrual cycle. The dosage is assigned individually. When determining the necessary dose of the drug, the patient's weight and her cycle are taken into account.

Clomid is administered for the first time on the 5th day of the cycle and on this (or the next) day the patient must be examined on ultrasound. The doctor will see if the growth of the egg has changed and what is the thickness of the endometrial layer. If the trend is not detected, the doctor may prescribe additional drugs that include estrogen.

During the entire cycle, after 5 days of using the drug to stimulate ovulation, the doctor will monitor the condition of the egg to determine the trends of its maturation. The question of a repeat procedure for Clovis may be raised if the first stage of therapy did not contribute to the onset of ovulation. At the second stage, the dose of the drug increases.

Traditionally, the following dosage options are used:

  • the maximum daily dose at the first stage of treatment-150 mg
  • for polycystic-50 mg / day
  • in case of ovarian depletion-100 mg / day simultaneously with estrogen therapy

Interaction

Clomiphene citrate is often used in combination with other drugs. For example, sometimes prescribed hormonal oral contraceptives short course (two to three months) and only then Clomiphene citrate. Sometimes a combination of Clomid and Metformin is used.

To make the stimulation more effective, it can be supplemented with gonadotropin therapy, for example, the drug "Proginova". The composition of "Proginova" includes synthetic estragen. "Proginova" and "Clomid" are assigned according to a special scheme:

  • on the fifth day of the cycle-5 days Clomid
  • when the ultrasound shows that the follicle has matured (managed to grow up to 20 mm), an injection of HCG is made to stimulate the formation of the yellow body
  • normally, after the HCG injection was made, ovulation occurs in about 2 days, and "proginova" is prescribed to prevent ovarian aging

Also, the therapy can be successfully supplemented with the drug "dufaston". Synthetic dydrogesterone, which contains the "main" is effectively helping the fertilization and maintenance of pregnancy, the analogue of natural progesterone.

Dufaston is taken in the second cycle phase and helps prepare the endometrium for pregnancy, improves the process of egg implantation and reduces the risk of termination of the pregnancy. "Dufaston" is also safe during pregnancy, while "Clomid" is potentially dangerous for the fetus and can not be taken if conception has occurred.

Simultaneous administration of the drugs "Proginova", "Clomid" and "dufaston" is prescribed quite often. But, of course, this should be decided by your doctor. He also decides to cancel the treatment.


When taking Clomid keep in mind

In polycystic ovary syndrome is often found in the resistance of the ovaries to clomiphene citrate. Simply put, the ovaries do not respond to treatment with the drug. Insensitivity ranges from 20 to 60%, which is a lot. Therefore, a special evaluation scale was developed that takes into account the patient's height, weight, ovarian volume and some hormonal indicators. An experienced doctor will necessarily analyze this data before prescribing "Clomid".

It is important to note that the thickness of the endometrium decreases during treatment with Clomid. If you have a thin endometrium, then usually doctors stimulate ovulation with other drugs.


Risks or side effects

Taking Clomid can be accompanied by side effects such as dizziness and headaches, nausea and occasional vomiting, anxiety, insomnia, weight gain, hair loss, etc.generally, negative reviews of the drug occur against the background of its long-term use.

When stimulated by the drug, more than one follicle can Mature, which leads to multiple pregnancies.

How many cycles with Clomid?

Clomid can not be used more than six courses in a lifetime, as this is fraught with a symptom of early ovarian depletion.


Efficiency

With directed treatment, the drug achieves the effect from the first cycle. The exception is patients with polycystic ovary syndrome. In this case, meets the resistance of the ovaries to clomiphene citrate. Simply put, the ovaries do not respond to treatment with the drug. Insensitivity ranges from 20 to 60%, which is a lot. Therefore, a special evaluation scale was developed that takes into account the patient's height, weight, ovarian volume and some hormonal indicators. An experienced doctor will necessarily analyze this data before prescribing "Clomid".

It is important to note that the thickness of the endometrium decreases during treatment with Clomid. If you have a thin endometrium, then usually doctors stimulate ovulation with other drugs.

Can clomid cause cancer?

There are several seemingly contradictory statements:

  1. stimulation for patients with reduced AMH(anti-Muller hormone-produced by ovarian function)
  2. no more than 6 stimulations in a lifetime(ovaries are depleted)

In fact, using clomid more than 6 times in a lifetime for stimulation is PROHIBITED. The drug in large quantities has a destructive effect on the hormonal environment of the body. According to research, 70% of cases after twelve stimulations ended with breast cancer. In order to eliminate this nuance, the scientists who conducted the research made a margin of half. In other words, no more than 6 times. 6 or more stimulations in life-increase the risk of developing a malignant breast tumor.

Regarding the decrease in the supply of eggs (depletion) — this is due to the fact that if you stimulate clomid and in the normal state of the patient grows, for example, 2-3 antral follicles — then during stimulation, 4-5 may grow, and in the next cycle 6-7 follicles. In the normal state of the follicles, the ovaries would give out a minimum-the effect of clomiphene is 3 months. Therefore, there is indeed some truth in the earlier consumption of eggs. Because of the long-term effect of clomid.


Is it dangerous?

It is believed that "Clomid" is an outdated drug, and many doctors no longer use it to stimulate ovulation, replacing it with other, more modern drugs. Is that so?

That's not so. Clomiphene citrate ("Clomid") is still widely used in gynecology when ovulation stimulation is necessary. Ovulation induction is successful if the correct diagnosis is made and the cause of anovulation is determined.


What if it didn't help?

Then ovulation is stimulated with other drugs. These are hormonal medications "Menotropin", "Follitropin" and others. These are effective medications, but they are more likely than Clomiphene citrate to give side effects. Therefore, if your gynecologist is sure that "Clomid" will help you, usually start with it.


Congenital malformation

The drug starts a natural procedure for the release of an egg from the ovary into the fallopian tube(ovulation). It only affects the hypothalamus – pituitary – ovary arc indirectly, so clomiphene can not influence the formation and development of the fetus. The drug has no effect on the processes associated with the Union of the egg and sperm in the womb.

The active effect of Clomiphene citrate is aimed at starting the ovulation process. Cases in which there were birth defects and other abnormalities with the fetus after birth are not associated with Clomid.

Sex and Clomid

Ovulation does not last long - up to 48 hours. Therefore, immediately after the doctor on the ultrasound saw the exit of the egg from the ovary, she needs to have unprotected sex with a sexual partner. Moreover, the more times during these 48 hours they will have sex, the higher the probability of conception. But after ovulation is over, it will be much more difficult to get pregnant.

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